{"id":50024,"date":"2026-08-12T09:25:30","date_gmt":"2026-08-12T06:25:30","guid":{"rendered":"https:\/\/hyperpower.com.tr\/?p=50024"},"modified":"2026-08-14T06:25:11","modified_gmt":"2026-08-14T03:25:11","slug":"dolasim-sistemimiz-nasil-calisiyor-kalpten-hucrelere-uzanan-bir-yolculuk","status":"publish","type":"post","link":"https:\/\/hyperpower.com.tr\/en\/dolasim-sistemimiz-nasil-calisiyor-kalpten-hucrelere-uzanan-bir-yolculuk\/","title":{"rendered":"Dola\u015f\u0131m Sistemimiz Nas\u0131l \u00c7al\u0131\u015f\u0131yor?"},"content":{"rendered":"
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Kalpten en k\u00fc\u00e7\u00fck damarlara kadar kan dola\u015f\u0131m\u0131n\u0131n ard\u0131ndaki biyolojiyi; damar sa\u011fl\u0131\u011f\u0131, fibrin ve h\u00fccresel enerji \u00fczerinden inceliyoruz.\u00a0<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Kalpten Dokulara<\/h5>

Kan\u0131m\u0131z\u0131n damarlar\u0131m\u0131zda serbest\u00e7e akmas\u0131 kadar, gerekti\u011finde saniyeler i\u00e7inde p\u0131ht\u0131la\u015fabilmesi de ya\u015fam i\u00e7in kritik bir dengedir.<\/strong><\/p>

Kalbimiz bir g\u00fcn i\u00e7inde yakla\u015f\u0131k 100.000 kez at\u0131yor. Her at\u0131mla birlikte kan; akci\u011ferlerden ald\u0131\u011f\u0131 oksijeni, sindirim sisteminden gelen besinleri ve farkl\u0131 dokular aras\u0131nda ta\u015f\u0131nmas\u0131 gereken hormonlar\u0131 v\u00fccudun d\u00f6rt bir yan\u0131na ula\u015ft\u0131r\u0131yor. Ayn\u0131 dola\u015f\u0131m, h\u00fccresel metabolizma sonucunda olu\u015fan karbondioksit gibi maddelerin uzakla\u015ft\u0131r\u0131lmas\u0131na da arac\u0131l\u0131k ediyor.\u00b9<\/p>

Ancak sa\u011fl\u0131kl\u0131 bir dola\u015f\u0131m, kalbin kan\u0131 hareket ettirmesinden \u00e7ok daha fazlas\u0131n\u0131 i\u00e7eriyor. Damarlar\u0131n yap\u0131s\u0131 ve esnekli\u011fi, damarlar\u0131n i\u00e7 y\u00fczeyini kaplayan h\u00fccreler, kan\u0131n bile\u015fimi ve gerekti\u011finde devreye giren p\u0131ht\u0131la\u015fma mekanizmalar\u0131 ayn\u0131 sistemin birbirini tamamlayan par\u00e7alar\u0131. \u00dcstelik damarlar\u0131m\u0131z, kan\u0131n i\u00e7inden ge\u00e7ti\u011fi pasif kanallar de\u011fil; kan ak\u0131\u015f\u0131ndaki ve \u00e7evrelerindeki de\u011fi\u015fimleri alg\u0131layarak bunlara biyolojik olarak yan\u0131t veren canl\u0131 dokular.\u00b2<\/p>

Damarlar\u0131m\u0131z Sand\u0131\u011f\u0131m\u0131zdan Daha Aktif<\/h5>

Damarlar\u0131n kanla temas eden en i\u00e7 y\u00fczeyinde endotel<\/strong> ad\u0131 verilen, yaln\u0131zca tek h\u00fccre kal\u0131nl\u0131\u011f\u0131nda \u00f6zel bir tabaka bulunur. \u0130nceli\u011fine ra\u011fmen endotel, dola\u015f\u0131m sisteminin i\u015fleyi\u015finde olduk\u00e7a aktif bir role sahiptir. Kan ak\u0131\u015f\u0131ndaki de\u011fi\u015fimleri alg\u0131lar ve damarlar\u0131n geni\u015fleyip daralmas\u0131ndan inflamatuvar yan\u0131tlara ve p\u0131ht\u0131la\u015fmayla ili\u015fkili s\u00fcre\u00e7lere kadar pek \u00e7ok mekanizman\u0131n d\u00fczenlenmesine katk\u0131da bulunur.\u00b3<\/p>

Bu sistemin \u00f6nemli sinyal molek\u00fcllerinden biri nitrik oksittir (NO)<\/strong>. Endotel taraf\u0131ndan \u00fcretilen nitrik oksit, damar duvar\u0131ndaki d\u00fcz kas h\u00fccrelerine sinyal g\u00f6ndererek damar tonusunun d\u00fczenlenmesine yard\u0131mc\u0131 olur. Bu nedenle kardiyovask\u00fcler ara\u015ft\u0131rmalar yaln\u0131zca kalbin ne kadar g\u00fc\u00e7l\u00fc \u00e7al\u0131\u015ft\u0131\u011f\u0131na de\u011fil, endotel fonksiyonuna ve damarlar\u0131n de\u011fi\u015fen kan ak\u0131\u015f\u0131na nas\u0131l yan\u0131t verdi\u011fine<\/strong> de odaklan\u0131yor.\u2074<\/p>

Ya\u015f ilerledik\u00e7e arterlerin yap\u0131s\u0131nda ve esnekli\u011finde de\u011fi\u015fiklikler g\u00f6r\u00fclebiliyor. Endotel fonksiyonundaki de\u011fi\u015fimler ve oksidatif stres de vask\u00fcler ya\u015flanma ara\u015ft\u0131rmalar\u0131n\u0131n \u00f6nemli ba\u015fl\u0131klar\u0131 aras\u0131nda. Ancak damarlar\u0131n nas\u0131l ya\u015fland\u0131\u011f\u0131n\u0131 yaln\u0131zca takvim ya\u015f\u0131 belirlemiyor; fiziksel aktivite, beslenme, metabolik sa\u011fl\u0131k ve sigara kullan\u0131m\u0131 gibi ya\u015fam tarz\u0131 fakt\u00f6rleri de bu biyolojinin \u015fekillenmesinde rol oynuyor.\u2075<\/p>

Kan Neden S\u00fcrekli S\u0131v\u0131 Kal\u0131rken Gerekti\u011finde P\u0131ht\u0131la\u015fabiliyor?<\/h5>

Dola\u015f\u0131m sisteminin en dikkat \u00e7ekici dengelerinden biri tam da burada ortaya \u00e7\u0131k\u0131yor. Kan\u0131n damarlar\u0131n i\u00e7inde serbest\u00e7e hareket etmesi gerekirken, bir damar hasar g\u00f6rd\u00fc\u011f\u00fcnde kan kayb\u0131n\u0131 s\u0131n\u0131rlayacak mekanizmalar\u0131n da h\u0131zla devreye girmesi gerekiyor.<\/p>

Hasar olu\u015ftu\u011funda trombositler b\u00f6lgeye y\u00f6nelirken p\u0131ht\u0131la\u015fma sistemi de harekete ge\u00e7iyor. Bu s\u00fcre\u00e7te kanda \u00e7\u00f6z\u00fcnm\u00fc\u015f h\u00e2lde bulunan fibrinojen<\/strong>, fibrin<\/strong> ad\u0131 verilen lifli bir proteine d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcyor. Fibrin lifleri birbirine ba\u011flanarak p\u0131ht\u0131n\u0131n yap\u0131s\u0131n\u0131 g\u00fc\u00e7lendiren bir a\u011f meydana getiriyor.\u2076<\/p>

Ancak v\u00fccudumuz yaln\u0131zca fibrin olu\u015fturmakla kalm\u0131yor. Hasarl\u0131 b\u00f6lgenin onar\u0131m\u0131 ilerledi\u011finde art\u0131k ihtiya\u00e7 duyulmayan fibrin yap\u0131s\u0131n\u0131n kontroll\u00fc bi\u00e7imde par\u00e7alanmas\u0131 gerekiyor. \u0130\u015fte bu s\u00fcrece fibrinoliz<\/strong> ad\u0131 veriliyor. Bu sistemde plazmin ad\u0131 verilen enzim, fibrin a\u011f\u0131n\u0131n par\u00e7alanmas\u0131nda merkezi bir rol \u00fcstleniyor.\u2077<\/p>

Ba\u015fka bir ifadeyle dola\u015f\u0131m sistemi s\u00fcrekli iki ihtiyac\u0131 dengeliyor: gerekti\u011finde p\u0131ht\u0131 olu\u015fturabilmek ve art\u0131k ihtiya\u00e7 kalmad\u0131\u011f\u0131nda bu yap\u0131y\u0131 kontroll\u00fc bi\u00e7imde \u00e7\u00f6zebilmek.<\/strong> Bu nedenle fibrin ve fibrinoliz, dola\u015f\u0131m biyolojisi \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar\u0131n \u00f6nemli ba\u015fl\u0131klar\u0131 aras\u0131nda yer al\u0131yor.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Fibrinolitik Sistem Neden Ara\u015ft\u0131r\u0131l\u0131yor?<\/h5>

V\u00fccudumuz bir damar hasar g\u00f6rd\u00fc\u011f\u00fcnde kanamay\u0131 durdurmak i\u00e7in fibrinden olu\u015fan g\u00fc\u00e7l\u00fc bir a\u011f kurar. Onar\u0131m tamamland\u0131\u011f\u0131nda ise art\u0131k ihtiya\u00e7 duyulmayan bu yap\u0131n\u0131n kontroll\u00fc bi\u00e7imde par\u00e7alanmas\u0131 gerekir. Fibrinoliz<\/strong>, tam olarak bu do\u011fal dengeyi sa\u011flayan sistemdir.<\/p>

Bilim insanlar\u0131 uzun y\u0131llard\u0131r bu sistemin nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 ve baz\u0131 do\u011fal bile\u015fenlerin bu s\u00fcre\u00e7lerle nas\u0131l etkile\u015fime girdi\u011fini ara\u015ft\u0131r\u0131yor. Bunlardan biri de Nattokinase<\/strong>. Nattokinase’in hik\u00e2yesi, Japonya’da y\u00fczy\u0131llard\u0131r t\u00fcketilen natto<\/strong> adl\u0131 geleneksel g\u0131dayla ba\u015fl\u0131yor. Soya fasulyesinin belirli bakterilerle fermente edilmesi s\u0131ras\u0131nda do\u011fal olarak ortaya \u00e7\u0131kan bu enzim, 1980’lerde fibrin \u00fczerindeki etkilerinin g\u00f6zlemlenmesiyle bilim d\u00fcnyas\u0131n\u0131n dikkatini \u00e7ekti.\u2078<\/p>

Nattokinase’i ilgin\u00e7 k\u0131lan nokta, ara\u015ft\u0131rmalarda fibrinin par\u00e7alanmas\u0131 ve v\u00fccudun do\u011fal fibrinoliz mekanizmalar\u0131yla ili\u015fkili s\u00fcre\u00e7ler<\/strong> \u00fczerinden incelenmesi. Laboratuvar \u00e7al\u0131\u015fmalar\u0131n\u0131n yan\u0131 s\u0131ra insanlarda yap\u0131lan baz\u0131 k\u00fc\u00e7\u00fck ara\u015ft\u0131rmalarda da Nattokinase t\u00fcketiminin ard\u0131ndan p\u0131ht\u0131la\u015fma ve fibrinolizle ili\u015fkili baz\u0131 g\u00f6stergelerde de\u011fi\u015fiklikler g\u00f6zlemlendi.\u2079<\/p>

Ara\u015ft\u0131rmalar zamanla fibrinin \u00f6tesine de geni\u015fledi. Nattokinase bug\u00fcn kan bas\u0131nc\u0131 ve damar fonksiyonu gibi dola\u015f\u0131m sistemiyle ili\u015fkili farkl\u0131 alanlarda<\/strong> da inceleniyor. Ancak mevcut \u00e7al\u0131\u015fmalar\u0131n b\u00fcy\u00fckl\u00fckleri ve sonu\u00e7lar\u0131 birbirinden farkl\u0131; \u00f6zellikle uzun d\u00f6nem etkilerini anlayabilmek i\u00e7in daha kapsaml\u0131 klinik ara\u015ft\u0131rmalara ihtiya\u00e7 var.\u00b9\u2070<\/p>

Bu nedenle Nattokinase’i \u201ckan\u0131 suland\u0131ran\u201d veya belirli bir sa\u011fl\u0131k sorununu \u00f6nleyen bir bile\u015fen olarak tan\u0131mlamak yerine, v\u00fccudun fibrin dengesini ve dola\u015f\u0131m biyolojisini anlamaya y\u00f6nelik ara\u015ft\u0131rmalarda dikkat \u00e7eken do\u011fal bir enzim<\/strong> olarak de\u011ferlendirmek daha do\u011fru.<\/p>

Dola\u015f\u0131m Sistemimizi Nas\u0131l Destekleyebiliriz?<\/h5>

Dola\u015f\u0131m sa\u011fl\u0131\u011f\u0131n\u0131 desteklemek i\u00e7in ba\u015flang\u0131\u00e7 noktas\u0131 takviyelerden \u00f6nce g\u00fcnl\u00fck al\u0131\u015fkanl\u0131klard\u0131r. D\u00fczenli fiziksel aktivite<\/strong>, artan kan ak\u0131\u015f\u0131 arac\u0131l\u0131\u011f\u0131yla damar duvar\u0131nda biyolojik sinyaller olu\u015fturur ve endotel fonksiyonuyla ili\u015fkili adaptasyonlar\u0131 destekler. Uzun s\u00fcre hareketsiz kalmamak, dengeli beslenmek, yeterli ve kaliteli uyumak, sigaradan uzak durmak ve metabolik sa\u011fl\u0131\u011f\u0131 korumak da kardiyovask\u00fcler sa\u011fl\u0131\u011f\u0131n temel par\u00e7alar\u0131 aras\u0131nda yer al\u0131yor.\u2074<\/p>

Bilimsel ara\u015ft\u0131rmalar bunun yan\u0131nda dola\u015f\u0131m sisteminin farkl\u0131 katmanlar\u0131nda yer alan molek\u00fclleri ve do\u011fal bile\u015fikleri incelemeye devam ediyor. Nattokinase fibrin ve fibrinolitik sistemle ili\u015fkili mekanizmalar \u00fczerinden; CoQ10<\/a><\/span> mitokondriyal elektron transferi ve redoks dengesi \u00fczerinden; PQQ<\/a><\/span> ise mitokondri biyolojisi \u00fczerine y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fmalarla<\/strong> bu ara\u015ft\u0131rmalarda kar\u015f\u0131m\u0131za \u00e7\u0131kan \u00f6rnekler aras\u0131nda.<\/p>

Dola\u015f\u0131m sa\u011fl\u0131\u011f\u0131na b\u00fct\u00fcnc\u00fcl bakmak da tam olarak burada anlam kazan\u0131yor. Mesele yaln\u0131zca kalbin atmas\u0131 ya da kan\u0131n damarlar\u0131m\u0131zdan ge\u00e7mesi de\u011fil; kan, damar duvar\u0131, p\u0131ht\u0131la\u015fma-fibrinoliz dengesi ve h\u00fccresel enerji \u00fcretiminin birbiriyle uyum i\u00e7inde \u00e7al\u0131\u015fabilmesi.<\/strong> Sa\u011fl\u0131kl\u0131 ya\u015fam al\u0131\u015fkanl\u0131klar\u0131 bu sistemin temelini olu\u015ftururken, bilimsel ara\u015ft\u0131rmalar da bu karma\u015f\u0131k biyolojiyi ve onu destekleyebilecek mekanizmalar\u0131 anlamaya devam ediyor.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Kaynaklar<\/h5>
  1. Guyton AC, Hall JE.<\/strong> Textbook of Medical Physiology.<\/em> Elsevier. \u2014 Kalp, kan dola\u015f\u0131m\u0131 ve dola\u015f\u0131m sisteminin temel fizyolojisi.<\/li>
  2. Gimbrone MA Jr, Garc\u00eda-Carde\u00f1a G.<\/strong> Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circulation Research.<\/em> 2016;118(4):620\u2013636. \u2014 Endotel fonksiyonu, damar biyolojisi ve nitrik oksit.<\/li>
  3. Seals DR, Jablonski KL, Donato AJ.<\/strong> Aging and Vascular Endothelial Function in Humans. Clinical Science.<\/em> 2011;120(9):357\u2013375. \u2014 Ya\u015fla birlikte endotel fonksiyonu, damar yap\u0131s\u0131 ve oksidatif stres.<\/li>
  4. Chapin JC, Hajjar KA.<\/strong> Fibrinolysis and the Control of Blood Coagulation. Blood Reviews.<\/em> 2015;29(1):17\u201324. \u2014 Fibrin olu\u015fumu, p\u0131ht\u0131la\u015fma ve fibrinoliz aras\u0131ndaki biyolojik denge.<\/li>
  5. Weng Y, Yao J, Sparks S, Wang KY.<\/strong> Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. International Journal of Molecular Sciences.<\/em> 2017;18(3):523. \u2014 Nattokinase’in k\u00f6keni, fibrin\/fibrinoliz mekanizmalar\u0131 ve kardiyovask\u00fcler ara\u015ft\u0131rmalar.<\/li>
  6. Kurosawa Y, Nirengi S, Homma T, et al.<\/strong> A Single-Dose of Oral Nattokinase Potentiates Thrombolysis and Anti-Coagulation Profiles. Scientific Reports.<\/em> 2015;5:11601. \u2014 \u0130nsanlarda tek doz Nattokinase sonras\u0131 fibrinoliz ve p\u0131ht\u0131la\u015fmayla ili\u015fkili g\u00f6stergelerin incelendi\u011fi \u00e7al\u0131\u015fma.<\/li>
  7. Jensen GS, Lenninger M, Ero MP, Benson KF.<\/strong> Consumption of Nattokinase Is Associated with Reduced Blood Pressure and von Willebrand Factor. Integrated Blood Pressure Control.<\/em> 2016;9:95\u2013104. \u2014 Nattokinase, kan bas\u0131nc\u0131 ve vask\u00fcler parametreler \u00fczerine insan \u00e7al\u0131\u015fmas\u0131.<\/li>
  8. Brown DA, Perry JB, Allen ME, et al.<\/strong> Expert Consensus Document: Mitochondrial Function as a Therapeutic Target in Heart Failure. Nature Reviews Cardiology.<\/em> 2017;14:238\u2013250. \u2014 Kalbin y\u00fcksek enerji ihtiyac\u0131, kardiyomiyositler ve mitokondriyal enerji metabolizmas\u0131.<\/li>
  9. Crane FL.<\/strong> Biochemical Functions of Coenzyme Q10. Journal of the American College of Nutrition.<\/em> 2001;20(6):591\u2013598. \u2014 CoQ10’un elektron ta\u015f\u0131ma zincirindeki rol\u00fc ve antioksidan \u00f6zellikleri.<\/li>
  10. Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB.<\/strong> Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis Through cAMP Response Element-Binding Protein Phosphorylation and Increased PGC-1\u03b1 Expression. Journal of Biological Chemistry.<\/em> 2010;285(1):142\u2013152. \u2014 PQQ, PGC-1\u03b1 ve mitokondriyal biyogenez \u00fczerine deneysel \u00e7al\u0131\u015fma.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

    Kalpten en k\u00fc\u00e7\u00fck damarlara kadar kan dola\u015f\u0131m\u0131n\u0131n ard\u0131ndaki biyolojiyi; damar sa\u011fl\u0131\u011f\u0131, fibrin ve h\u00fccresel enerji \u00fczerinden inceliyoruz.<\/p>","protected":false},"author":2,"featured_media":50036,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-50024","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel"],"acf":[],"_links":{"self":[{"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/posts\/50024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/comments?post=50024"}],"version-history":[{"count":10,"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/posts\/50024\/revisions"}],"predecessor-version":[{"id":50045,"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/posts\/50024\/revisions\/50045"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/media\/50036"}],"wp:attachment":[{"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/media?parent=50024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/categories?post=50024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hyperpower.com.tr\/en\/wp-json\/wp\/v2\/tags?post=50024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}